Dr. Gloria Tobajas Curiel

PhD: University of Cambridge

Previous Position: PhD Candidate with Prof. Chris Hunter, University of Cambridge

Research: Simultaneous force and spectroscopic characterisation of chemical double mutant cycles at the single-molecule level

ORCID: 0000-0003-0022-834X

Group webpage: Chemistry of Low-Dimensional Materials

Joining Date: October 2023

User Name: gloria.tobajas

Telephone: 8838

Gloria Tobajas Curiel graduated with a Pharmacy degree (MPharm) from Universidad Complutense de Madrid in 2015, which was followed by an MSc in Drug Discovery where she worked on the synthesis of small molecules structurally related to natural polyphenols at Instituto de Química Médica (IQM-CSIC). Prior to the beginning of her PhD, she was awarded a fellowship sponsored by Fundación Universidad-Empresa (FUE) to join Janssen Pharma as a medicinal chemist. Between 2018-2023, she carried out her PhD studies in the group of Chris Hunter at the University of Cambridge where she investigated non-covalent interactions in synthetic and biological systems.

Gloria’s current research interests lie in the understanding of the relationship between structure and function in chemistry, biology, and material sciences through the systematic study of molecular recognition. In late 2023, she joined the group of Emilio Pérez at IMDEA Nanociencia as a postdoctoral researcher to work on the characterisation of non-covalent chemistries under non-equilibrium conditions using single-molecule force spectroscopy techniques.

Relevant publications

G. Tobajas-Curiel, Q. Sun, J. K. M. Sanders, P. Ballester, C. A. Hunter. Solvation Rules: Aromatic Interactions Outcompete Cation-π Interactions in Synthetic Host-Guest Complexes in Water. Chem. Comm., 2023, 59, 14146-14148.

G. Tobajas-Curiel, Q. Sun, J. K. M. Sanders, P. Ballester, C. A. Hunter. Aromatic Interactions with Heterocycles in Water. Chem. Sci., 2023, 14, 11131-11140.

G. Tobajas-Curiel, Q. Sun, J. K. M. Sanders, P. Ballester, C. A. Hunter. Substituent Effects on Aromatic Interactions in Water. Chem. Sci., 2023, 14, 6226-6236.

D. Quaglio, N. Zhdanovskaya, G. Tobajas, V. Cuartas, S. Balducci, M.S. Christodoulou, G. Fabrizi, M. Gargantilla, E. M. Priego, A. Carmona-Pestaña, D. Passarella, I. Screpanti, B. Botta, R. Palermo, M. Mori, F. Ghirga, M. J. Peŕez-Peŕez. Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia. ACS Med. Chem. Lett., 2019, 10, 639-643.

O. Bueno, G. Tobajas, E. Quesada, J. Estévez-Gallego, S. Noppen, M. J. Camarasa, J. F. Díaz, S. Liekens, E. M. Priego, M. J. Pérez-Pérez. Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. Eur. J. Med. Chem., 2018, 148, 337-348.